Lot Acceptance Decision Specification

This specification defines the Quality Unit–approved acceptance decision criteria and decision logic governing acceptance, rejection, or further evaluation of lots based on sampling and test results.

Specification Type:
Authoritative Quality Control specification defining lot acceptance decision criteria and decision authority. This document does not define sampling execution, statistical calculations, or laboratory test methods.

1. Purpose

To establish Quality Unit–approved decision requirements governing how sampling and test results are evaluated to determine lot acceptance, rejection, or the need for additional evaluation.

2. Scope

This specification applies to all lots of components, raw materials, in-process materials, finished products, and packaging components where sampling results are used to support quality decisions.

Applicable Business Domains include:

3. Ownership & Governance

Lot acceptance decision criteria defined in this specification shall not be modified outside approved QMS change control.

4. Lot Acceptance Decision Criteria

Sampling Outcome Decision Requirement Resulting Status
All results meet acceptance criteria Lot may be accepted for its intended GMP use Accepted
One or more results outside acceptance criteria Lot shall not be accepted without Quality Unit evaluation Rejected or Under Evaluation
Atypical, borderline, or inconclusive results Additional evaluation or investigation is required Under Evaluation
Sampling plan deviations or invalid results Results shall not be used to support acceptance decisions Decision Deferred

Lot acceptance decisions shall be based on results generated from approved sampling plans and evaluated against approved acceptance criteria.

5. Decision Logic

6. Escalation Requirements

Quality Assurance must escalate to Quality Control or QCO when any of the following occur:

7. Records & Evidence

Records supporting compliance with this specification include, but are not limited to:

This specification defines lot acceptance decision criteria and authority only. Statistical evaluation, retesting practices, and laboratory execution are defined in separate controlled documents and shall not redefine the requirements herein.