This specification defines Quality Unit–approved environmental acceptance criteria for GMP-designated production areas to ensure controlled manufacturing conditions that protect product identity, purity, strength, composition, and safety.
This specification applies to all GMP-classified production areas where manufacturing, blending, encapsulation, tableting, or in-process handling of materials or product occurs.
The environmental acceptance criteria defined below represent Quality Unit–approved requirements governing production area conditions. These criteria establish the allowable operating limits used to support consistent process performance and product quality.
These values are authoritative and shall not be modified, reinterpreted, or duplicated in procedures, work instructions, or records outside this specification.
| Controlled Parameter | Approved Acceptance Criteria | Decision Authority |
|---|---|---|
| Production Area Ambient Temperature | 68°F to 77°F | Quality Unit (QCO) |
| Production Area Relative Humidity | ≤ 50% RH | Quality Unit (QCO) |
Execution of environmental monitoring, alarm response, and documentation is performed by Quality Assurance and applicable Business Domains in accordance with approved procedures.
Records generated through monitoring systems and logs constitute objective evidence of compliance with this specification.